cómo se transporta la glucosa través de la membrana celular? diana díaz hernández, luis carlos burgos herrera de la célula para su ingreso requiere una. RESUMEN El transporte de la glucosa a través de la membrana plasmática de a sodio (SGLT) y los sistemas facilitadores del transporte de glucosa (GLUT). Se han descrito dos sistemas de transporte de glucosa y de otros monosacáridos : y los transportadores de glucosa llamados GLUT (glucosa transporters).
|Published (Last):||6 September 2015|
|PDF File Size:||17.86 Mb|
|ePub File Size:||3.39 Mb|
|Price:||Free* [*Free Regsitration Required]|
Structure and function of mammalian facultative sugar transporters. Protein pages needing a picture. Regulation of glucose-transporter function. Close genetic linkage between HLA and renal glycosuria. In obesity, the GLUT4 content is not diminished providing that insulin sensitiveness is gluys.
Glucose transporter in insulin sensitive tissues of lean and obese mice. Cloning of a human cDNA with similarity to the sodium-glucose cotransporter.
Quantification of GLUT4 transporter in insulin-sensitive tissues from pinealectomized rats. Is a bidirectional transporter, allowing glucose to flow in 2 directions. It is plausible to propose that the modulation of GLUT4 is triggered by a combination gouts factors indicating cellular sensitiveness to insulin.
Membrane Transport and Metabolism. Transcription repressed by glucose.
De Vivo’s syndrome, described in convulsive infants with hypoglycorrachia during normoglycaemia, has been attributed to a reduction in the GLUT1 content in endothelial cells at the blood-brain barrier. How to cite this article. Transport proteins Integral membrane proteins. Bidirectionality is required in liver cells to uptake glucose for glycolysis and glygogenesis, and release glucisa glucose during gluconeogenesis.
Found in adipose tissues and striated muscle skeletal muscle and cardiac muscle. Vesicular glutamate transporter 1 SLC32A1.
Transportador de glucosa
Is widely distributed in fetal tissues. In other projects Wikimedia Commons. N Engl J Med ; J Cell Biol ; Decreased expression of glucose transporter in muscle from insulin-resistant patients. Is expressed by renal tubular cells, liver cells and pancreatic beta cells. GLUTs are integral membrane proteins that goucosa 12 membrane-spanning helices with both the amino and carboxyl termini exposed on the cytoplasmic side of the plasma membrane.
Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglcyrrachia, seizures, and developmental delay. Is a high-affinity isoform, allowing it to transport even in times of low glucose concentrations. Most members of classes II and III have been identified recently in homology searches of EST databases and the sequence information provided by the various genome projects. Int J Obes ; Reversible redox-dependent interconversions of tetrameric and dimeric GLUT1″.
Expressed mostly in neurons where it is believed to be the main glucose transporter isoformand in the placenta. Abundant during stationary phase, sporulation and low glucose conditions.
Fructose transporter in human spermatozoa and small intestine is GLUT5. A topologia dos transportadores de glicose GLUTs inicialmente proposta por Mueckler e cols 2 para o GLUT 1, e posteriormente confirmada para as outras isoformas 12e pode ser vista na Figura 1.
Cloning sequence, and expression of the pantothenate permease panF gene of Escherichia coli. The Metabolic Basis of Inherited Diseases.
Transportadores de glucosa by Jose Rodriguez on Prezi
From Molecular Mechanisms to Clinical Implications. Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transportavores in Glucosw skeletal muscle cells. It is also present in the basolateral membrane of the small intestine epithelium. Effect of the thermogenic agent BRL A. Nucleotide sequence of putP, the proline carrier of Escherichia coli K In familial renal glycosuria, the participation of SGLT2 and SGLT1 seems to be fundamental, either by loss of transport capacity or by decrease in the transporter affinity.
Tese – Mestrado -Escola Paulista de Medicina. Usually produced only in hepatocytesin fasting conditions, other tissues such as the intestines, muscles, brain, and kidneys are able to produce glucose following activation of gluconeogenesis.
Binding of glucose to one site provokes a conformational change associated with transport, and releases glucose to the other side of the membrane.
J Clin Invest ; Diabetes Glutx ; Machado UF, Saito M.
GLUT4 – Viquipèdia, l’enciclopèdia lliure
A Cellular Transprtadores Molecular Approaoch. Evidence for a family of human glucose transporter-like proteins. Molecular physiology of glucose transporters. Each glucose transporter isoform plays a specific role in glucose metabolism determined by its pattern of tissue expression, substrate specificity, transport kinetics, and regulated expression in different physiological conditions.
Structure and function of hexose transporters.